Brain Toxicokinetics of Prometryne in Mice
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چکیده
منابع مشابه
Brain toxicokinetics of prometryne in mice.
Prometryne is a methylthio-s-triazine herbicide. Significant trace amounts are found in the environment, mainly in water, soil, and food plants. The aim of this study was to establish brain and blood prometryne levels after single oral dose (1 g kg-1) in adult male and female mice. Prometryne was measured using the GC/MS assay at 1, 2, 4, 8, and 24 h after prometryne administration. Peak brain ...
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BACKGROUND Paraquat (PQ) has been implicated as a risk factor for the Parkinson disease phenotype (PDP) in humans and mice using epidemiologic or experimental approaches. The toxicokinetics (TK) and toxicodynamics (TD) of PQ in the brain are not well understood. OBJECTIVES The TK and TD of PQ in brain were measured after single or repeated doses. METHODS Brain regions were analyzed for PQ l...
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ژورنال
عنوان ژورنال: Archives of Industrial Hygiene and Toxicology
سال: 2010
ISSN: 0004-1254
DOI: 10.2478/10004-1254-61-2010-1986